Author

Josh M. Gorham

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Jonathan G. SeidmaniD· 3 shared Aditi ShuklaiD· 1 shared Amanda C. GarfinkeliD· 1 shared Angela C. Tai· 1 shared Anne E. DodsoniD· 1 shared Barbara A. McDonoughiD· 1 shared Charles Keith OzakiiD· 1 shared Charles S RedwoodiD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersSystems Biology

Jonathan G. SeidmanORCID

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Author profile →

3 papers

Recent·Most cited

Short-term Pre-operative Methionine Restriction Induces Browning of Perivascular Adipose Tissue and Improves Vein Graft Remodeling in Mice

Peter Kip, Thijs J. Sluiter, Michael Robert MacArthur, Ming Tao, Jonathan Jung, Sarah Jayne Mitchell, Sander Kooijman, Nicky Kruit, Josh M. Gorham, Jonathan G. Seidman, Paul H.A. Quax, Masanori Aikawa, Charles Keith Ozaki, James R. Mitchell, Margreet R. de Vries

bioRxiv · Nov 2, 2023 · PreprintSystems Biology

poly(UG)-tailed RNAs in Genome Protection and Epigenetic Inheritance

Aditi Shukla, Jenny Jiacheng Yan, Daniel J. Pagano, Anne E. Dodson, Yuhan Fei, Josh M. Gorham, Jonathan G. Seidman, Marvin Wickens, Scott G. Kennedy

The paper shows that pUG tails on RNAs enable transgenerational epigenetic inheritance by promoting gene silencing through siRNA synthesis in C. elegans.

Nature · May 20, 2020Peer-reviewedMolecular Biology

MYBPC3 Mutations cause Hypertrophic Cardiomyopathy by Dysregulating Myosin: Implications for Therapy

Christopher N. Toepfer, Hiroko Wakimoto, Amanda C. Garfinkel, Barbara A. McDonough, Dan Liao, Jianming Jiang, Angela C. Tai, Josh M. Gorham, Ida Gjervold Lunde, Mingyue Lun, Thomas L. Lynch, Sakthivel Sadayappan, Charles S Redwood, Hugh C Watkins, Jonathan G. Seidman, Christine E. Seidman

The paper shows that MYBPC3 mutations disrupt myosin relaxation states, leading to hyper-contractility in HCM, and that targeting myosin can alleviate these effects.

bioRxiv · Apr 18, 2018 · PreprintGenetics