NAD+ Sensing by PARP7 Regulates the C/EBPβ-Dependent Transcription Program in Adipose Tissue In Vivo
MiKayla S Stokes, Yoon Jung Kim, Yonghyeon Kim, Sneh Koul, Shu-Ping Chiu, Morgan Dasovich, Josue Zuniga, Tulip Sunil Nandu, Dan Yang Huang, Thomas P. Mathews, Ashley Solmonson, Cristel V. Camacho, W. Lee Kraus
This study identifies PARP7 as a key regulator of C/EBPβ-dependent adipogenesis and shows it senses nuclear NAD+ levels to control gene expression and lipid production in mammary glands.
bioRxiv · Apr 7, 2025 · PreprintCell Biology