Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
Erik Schäffner, Mar Bosch-Queralt, Julia M. Edgar, Maria Lehning, Judith Strauß, Niko Fleischer, Theresa Kungl, Peter Wieghofer, Stefan A. Berghoff, T. Reinert, Martin Krueger, Markus Morawski, Wiebke Möbius, Alonso Barrantes‐Freer, Jens Stieler, , Ruth Martha Stassart
The paper challenges the view that axonal degeneration in MS results from immune-mediated damage by proposing that myelin itself increases axonal degeneration risk under inflammatory conditions.
Nature Neuroscience · Jun 29, 2023Peer-reviewedNeuroscience