Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells
Sarah Staudt, Fabian Nikolka, Markus Perl, Julia Franz, Noémie Leblay, Xiaoli-Kat Yuan, M. Larrayoz, Teresa Lozano, Linda Warmuth, Matthias A. Fante, Aistė Skorupskaitė, Teng Fei, Maria Bromberg, Patxi San Martín‐Úriz, Juan R. Rodríguez-Madoz, , Maik Luu
This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.
bioRxiv · Aug 19, 2024 · PreprintImmunology