Author

Alexander Visekruna

Philipps University of MarburgORCID 0000-0002-5207-9545Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Aistė Skorupskaitė· 1 shared Alan BeausangiD· 1 shared Anne Hellhund· 1 shared Axel PagenstecheriD· 1 shared Beatriz Gil· 1 shared Christoph K. Stein‐ThoeringeriD· 1 shared David Clifford HenshalliD· 1 shared Dirk Hans BuschiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Aistė Skorupskaitė

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells

Sarah Staudt, Fabian Nikolka, Markus Perl, Julia Franz, Noémie Leblay, Xiaoli-Kat Yuan, M. Larrayoz, Teresa Lozano, Linda Warmuth, Matthias A. Fante, Aistė Skorupskaitė, Teng Fei, Maria Bromberg, Patxi San Martín‐Úriz, Juan R. Rodríguez-Madoz, , Maik Luu

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.

bioRxiv · Aug 19, 2024 · PreprintImmunology

Immunoproteasome deficiency results in accelerated brain aging and epilepsy

Hanna Leister, Felix F. Krause, Beatriz Gil, Ruslan Prus, Inna Prus, Anne Hellhund, Meghma Mitra, Rogério R. Gerbatin, Norman Delanty, Alan Beausang, Francesca M. Brett, Michael A. Farrell, Jane Cryen, Donncha F. O’Brien, David Clifford Henshall, , Tobías Engel

This study shows that immunoproteasome deficiency accelerates brain aging and causes epilepsy in mice, with reduced immunoproteasome expression also observed in human epilepsy patients.

bioRxiv · Mar 30, 2023 · PreprintNeuroscience