Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice
Emanuela Ricciotti, Soon Yew Tang, Antonijo Mrčela, Ujjalkumar Subhash Das, Ronan Lordan, Robin Joshi, Soumita Ghosh, Justin Aoyama, Ryan A. McConnell, Jianing Yang, Gregory R. Grant, Garret A. FitzGerald
This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.
bioRxiv · Jul 2, 2024 · PreprintPharmacology & Toxicology