Ujjalkumar Subhash Das

This study uses single-cell RNA sequencing to analyze circadian rhythms in mouse aorta cells and shows how acute misalignment disrupts these rhythms and vascular function.

This paper identifies PACERR as a lncRNA that regulates COX-2 and cholesterol transport genes, linking inflammation and cholesterol homeostasis through distinct mechanisms in response to HDL and LPS.

The paper shows that suppressing both COX-1 and COX-2 does not cause intestinal injury in mice unless combined with specific NSAIDs, and that gut microbiome changes amplify NSAID-induced enteropathy.

This study shows that COX-2 deletion or inhibition leads to heart failure with preserved ejection fraction in zebrafish, mice, and humans.

This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.

This study shows that disrupting PGF2α receptor signaling reduces fibrosis in a mouse model of IPF by altering fibroblast dynamics and reducing fibrotic endpoints.