Author

K. A. Fontaine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

K. E. Leon· 3 shared M. M. Khalid· 3 shared M. Ott· 3 shared C. R. Simoneau· 2 shared D. Jimenez-Morales· 2 shared J. A. Kaye· 2 shared M. Dunlap· 2 shared N. J. Krogan· 2 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

K. E. Leon

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

C. R. Simoneau, P.-Y. Chen, G. X. Xing, M. M. Khalid, N. L. Meyers, J. M. Hayashi, T. Y. Taha, K. E. Leon, T. Ashuach, K. A. Fontaine, L. Rodriguez, B. Joehnk, K. Walcott, S. Vasudevan, X. Fang, , M. Ott

The paper uses ACE2-overexpressing airway organoids to show NF-κB inhibitor alpha is upregulated during SARS-CoV-2 infection and its reduced function increases viral infection.

bioRxiv · Aug 2, 2022 · PreprintMicrobiology

Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function

K. E. Leon, R. E. Flynn, M. M. Khalid, K. A. Fontaine, T. Nguyen, R. Kumar, C. R. Simoneau, S. Tomar, D. Jimenez-Morales, M. Dunlap, J. A. Kaye, P. S. Shah, S. Finkbeiner, N. J. Krogan, C. Bertozzi, , M. Ott

This study shows ZIKV infection disrupts UPF1 function, leading to nuclear mRNA accumulation and impaired neural progenitor cell function.

bioRxiv · Dec 3, 2020 · PreprintMicrobiology

The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein

K. A. Fontaine, K. E. Leon, M. M. Khalid, S. Tomar, D. Jimenez-Morales, M. Dunlap, J. A. Kaye, P. S. Shah, S. Finkbeiner, N. J. Krogan, M. Ott

This study shows that ZIKV infection disrupts the NMD pathway by interacting with UPF1 via its capsid protein, enhancing viral infection and contributing to neuropathology.

bioRxiv · Oct 4, 2018Microbiology