S. Tomar

Viral methyltransferase inhibitors: berbamine, venetoclax, and ponatinib as efficacious antivirals against Chikungunya virus

This paper identifies three FDA-approved drugs as inhibitors of Chikungunya virus nsP1 methyltransferase, showing antiviral efficacy in cell-based assays.

Enhancing affinity of neutralizing SARS-CoV-2 nanobody through facile structure-guided mutations in CDRs

This study enhances the affinity of SARS-CoV-2 neutralizing nanobodies through structure-guided mutations in CDRs, resulting in improved neutralization activity against pseudovirus.

Targeting the host protein G3BP1 for the discovery of novel antiviral inhibitors against Chikungunya virus

This study identifies seven small molecules that inhibit Chikungunya virus replication by targeting the G3BP1 protein's FGDF binding pocket.

SAM-dependent viral MTase inhibitors: herbacetin and caffeic acid phenethyl ester, structural insights into dengue MTase

The paper identifies herbacetin and caffeic acid phenethyl ester as inhibitors of dengue and chikungunya virus MTases, revealing their mechanism of action and antiviral efficacy.

Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1

This study shows that SERMs inhibit alphavirus infection by targeting the viral capping enzyme nsP1, with antiviral effects observed in cell culture and mice.

Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function

This study shows ZIKV infection disrupts UPF1 function, leading to nuclear mRNA accumulation and impaired neural progenitor cell function.

The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein

This study shows that ZIKV infection disrupts the NMD pathway by interacting with UPF1 via its capsid protein, enhancing viral infection and contributing to neuropathology.