E. Chevet

LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation

This study identifies LRRK2 as a regulator of the unfolded protein response and antigen presentation in macrophages during inflammation, linking it to immune response mechanisms.

Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer

This study investigates genomic and transcriptomic alterations of AGR2 and AGR3 in cancer using multiple databases, finding no functional polymorphisms or recurrent mutations, but associations with cancer features and gene expression patterns.

IRE1 RNase controls CD95-mediated cell death

This study shows that IRE1 RNase activity regulates CD95 expression and cell death in cancer cells, with implications for therapeutic targeting.

Anterior Gradient-2 (AGR2) is overexpressed in colon cancer and is a potential biomarker of microsatellite instability (MSI) tumors

This study finds AGR2 protein is overexpressed in colon cancer and correlates with longer survival, and is associated with microsatellite instability (MSI) tumors.

p97/VCP induces GLI1 to control XBP1-dependent endoplasmic reticulum stress transcriptional response

The paper shows p97/VCP interacts with RUVBL2 and mSin3A-HDAC1/2 to regulate GLI1, which activates XBP1 under ER stress, independent of Hh ligands.

SARS-CoV2 envelop proteins reshape the serological responses of COVID-19 patients

This study examines the immunogenic potential of SARS-CoV-2 envelope proteins, showing that Spike and Membrane proteins elicit specific IgG, IgM, and IgA responses, with reduced Ig binding observed for the Spike G614 variant.

Reflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors

The paper identifies a mechanism where ER proteins are refluxed to the cytosol, inactivating tumor suppressors like p53 in glioblastoma cells.

Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.

This study identifies RtcB tyrosine phosphorylation as a regulatory mechanism controlling IRE1's dual RNase activities, influencing cell survival or death during ER stress.

Local intracerebral Inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo.

The paper develops a novel immunocompetent GBM model to test the effect of IRE1 inhibition on treatment efficacy in vivo.

Novel IRE1-dependent proinflammatory signaling controls tumor infiltration by myeloid cells.

This study identifies an IRE1-dependent proinflammatory signaling pathway in glioblastoma that promotes tumor invasion, angiogenesis, and myeloid cell infiltration.

Constitutive UPRER activation sustains tumor cell differentiation

The paper shows that constitutive IRE1 activation maintains differentiation in glioblastoma cells by repressing stemness factors.