B. Tirosh

KIRA6 is an effective and versatile mast cell inhibitor of IgE-mediated activation

This study identifies KIRA6 as a dual inhibitor of LYN and FYN that suppresses IgE-mediated mast cell activation and inflammation.

DR5 disulfide bonding as a sensor and effector of protein folding stress

This study shows that disrupting DR5 disulfide bonds activates pro-apoptotic signaling and reveals DR5 disulfide bonding as a sensor and effector of ER stress in cancer cells.

Novel IRE1-dependent proinflammatory signaling controls tumor infiltration by myeloid cells.

This study identifies an IRE1-dependent proinflammatory signaling pathway in glioblastoma that promotes tumor invasion, angiogenesis, and myeloid cell infiltration.

Repression of Viral Gene Expression and Replication by the Unfolded Protein Response Effector XBP1u

This study shows that MCMV uses the UPR to regulate its life cycle by activating the IRE1-XBP1 pathway to counteract XBP1u repression of viral gene expression and replication.

Constitutive UPRER activation sustains tumor cell differentiation

The paper shows that constitutive IRE1 activation maintains differentiation in glioblastoma cells by repressing stemness factors.

{-}{-}{-}{-}{-}Polyglutamine-related aggregates serve as a potent antigen source for cross presentation by dendritic cells

The paper shows that polyglutamine-related aggregates from apoptotic cells are efficiently processed by dendritic cells for cross-presentation, ensuring antigenic overlap necessary for T cell immunity.