Author

K. D. DeMarco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

J. Li· 2 shared K. C. Murphy· 2 shared L. Chibaya· 2 shared L. J. Zhu· 2 shared A. Kulick· 1 shared C. F. Lusi· 1 shared C. N. Parikh· 1 shared E. De Stanchina· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

J. Li

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Author profile →

2 papers

Recent·Most cited

Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer

L. Chibaya, C. F. Lusi, K. D. DeMarco, G. I. Kane, M. L. Brassil, C. N. Parikh, K. C. Murphy, J. Li, T. E. Naylor, J. Cerrutti, J. Peura, J. R. Pitarresi, L. J. Zhu, K. A. Fitzgerald, P. U. Atukorale, M. A. Ruscetti

This paper combines nanoparticle-delivered immune agonists with senescence-inducing agents to enhance T cell responses and control pancreatic cancer in preclinical models.

bioRxiv · Sep 18, 2023 · PreprintCancer Biology

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

L. Chibaya, K. C. Murphy, Y. Lopez-Diaz, K. D. DeMarco, H. Liu, S. Gopalan, M. Faulkner, J. Li, J. P. Morris, Y.-J. Ho, J. Simon, W. Luan, A. Kulick, E. De Stanchina, K. Simin, , M. Ruscetti

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

bioRxiv · Jun 21, 2022Cancer Biology