K. C. Murphy

Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer

This paper combines nanoparticle-delivered immune agonists with senescence-inducing agents to enhance T cell responses and control pancreatic cancer in preclinical models.

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

Phase variation as a major mechanism of adaptation in Mycobacterium tuberculosis complex

The paper identifies phase variation in Mycobacterium tuberculosis complex as an adaptive mechanism, showing it alters gene expression and virulence.

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

This study maps chemical-genetic interactions in Mycobacterium tuberculosis to identify how carbon metabolism and cell wall structure affect drug efficacy, revealing environment-dependent and -independent interactions.

A large inner membrane pore defines the ESX translocon

The paper reports the cryo-EM structure of the ESX-3 secretion system, revealing a large pore capable of translocating folded substrates and a regulatory cytoplasmic complex.

Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes

This study uses a novel chemical-genetics screening strategy to identify new inhibitors of Mycobacterium tuberculosis, revealing novel compound classes targeting previously unexplored bacterial targets.