Author

S. Gopalan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

T. G. Fazzio· 3 shared A. A. Godbole· 1 shared A. D. Durbin· 1 shared A. K. Walker· 1 shared A. Kulick· 1 shared A. L. Munden· 1 shared C. A. Lewis· 1 shared E. De Stanchina· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

T. G. Fazzio

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PRMT5 orchestrates EGFR and AKT networks to activate NFκB and promote EMT

L. Huang, M. Ravi, X.-O. Zhang, O. Verdejo-Torres, N. A. M. Shendy, M. A. M. Nezhady, S. Gopalan, G. Wang, A. D. Durbin, T. G. Fazzio, J. Q. Wu

This study identifies PRMT5's role in promoting EMT in neuroblastoma by regulating EGFR and AKT pathways, leading to NFκB activation and tumor growth.

bioRxiv · Jan 3, 2024 · PreprintCancer Biology

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

L. Chibaya, K. C. Murphy, Y. Lopez-Diaz, K. D. DeMarco, H. Liu, S. Gopalan, M. Faulkner, J. Li, J. P. Morris, Y.-J. Ho, J. Simon, W. Luan, A. Kulick, E. De Stanchina, K. Simin, , M. Ruscetti

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

bioRxiv · Jun 21, 2022Cancer Biology

S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

A. A. Godbole, S. Gopalan, T.-K. Nguyen, A. L. Munden, P. Vo, C. A. Lewis, J. B. Spinelli, T. G. Fazzio, A. K. Walker

The paper identifies distinct roles of SAMS-1 and SAMS-4 in regulating H3K4me3 and gene expression during heat stress in C. elegans.

bioRxiv · Mar 30, 2022Cell Biology