N. Kannan

The Mayo Clinic Salivary Tissue-Organoid Biobanking: A Resource for Salivary Regeneration Research

The paper establishes a salivary regenerative biobank and identifies markers and proteomic signatures of salivary gland stem and progenitor cells.

Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

This study investigates how redox regulation via cysteine oxidation controls BRSK1/2 kinase activity, revealing conserved mechanisms that modulate catalytic function through disulfide bond formation and salt bridge disruption.

Microbiome Prevents Sudden Death Through Occult Cardiac Sub-micrometastasis in Mice

The paper shows that gut microbiota prevents sudden cardiac death in mice by suppressing occult cardiac sub-micrometastases.

Context-specific GITR agonism potentiates anti-PD-L1 and CD40-based immuno- chemotherapy combination in heterogeneous pancreatic tumors

This study identifies GITR agonism as a potential enhancer of anti-PD-L1 and CD40-based immunotherapy in pancreatic tumors by targeting immune evasion mechanisms.

Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases

This study investigates how isoform-specific variations in DCLK family kinases affect autoregulation through structural and functional analyses.

Levo in fimo test : A simple test for fecal microbial reconstituted mice

The paper introduces a simple test to monitor gut microbial reconstitution in germfree mice using fecal floatation in Trumps fixative solution.

Evolutionary and cellular analysis of the dark pseudokinase PSKH2

This study investigates the evolutionary and cellular roles of the pseudokinase PSKH2, confirming its catalytic inactivity and identifying its mitochondrial localization and chaperone-dependent regulation.

Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters

This study improves prenylation predictions in yeast using machine learning, identifying new motifs and distinguishing cleaved from shunted sequences.

Evolution of functional diversity in the holozoan tyrosine kinome

This study classifies holozoan tyrosine kinases using sequence constraints, identifies new subgroups, and links functional diversity to evolutionary changes in kinase domains.

Barcoded Competitive Clone-Initiating Cell (BC-CIC) Analysis Reveals Differences in Ovarian Cancer Cell Genotype and Niche Specific Clonal Fitness During Growth and Metastasis In Vivo

This paper introduces a clonal tracking system using DNA barcoding and computational analysis to study metastatic clone fitness and genotype effects in ovarian cancer.

KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases

KinOrtho maps human kinase orthologs across 17,000 species, identifies understudied kinases, and proposes their functions using domain-based approaches and machine learning.

Nucleotide binding, evolutionary insights and interaction partners of the pseudokinase Unc-51-like kinase 4

This study presents the structure of ULK4-ATPγS complex, identifies disease mutations affecting ATP binding, and reveals ULK4's interaction partners and evolutionary adaptations.

Distinct Long-term Effects of Precision X-Radiation on Reflex Saliva Flow Rate and Tissue Integrity in a Preclinical Model of Chronic Hyposalivation

This study develops a novel preclinical model to assess long-term effects of precision radiation on salivary function and tissue integrity in mice.

A novel redox-active switch in Fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily

This study identifies redox-sensitive cysteines in Fructosamine-3-kinases (FN3Ks) that regulate their activity and dimerization through disulfide bonds, revealing a novel redox regulatory mechanism in the protein kinase superfamily.

LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena

This study identifies LF4/MOK and CDKR1 as regulators of cilium length and number in Tetrahymena, showing LF4A inhibits intraflagellar transport and CDKR1 modulates LF4A activity.

An evolutionary-conserved redox regulatory mechanism in human Ser/Thr protein kinases

The study identifies a conserved redox regulatory mechanism in human Ser/Thr kinases through cysteine oxidation in the activation segment.

Genetic variation/evolution and differential host responses resulting from in-patient adaptation of Mycobacterium avium

This study examines genetic changes in Mycobacterium avium isolates from infected patients over time and links these changes to altered host immune responses and increased bacterial persistence.