Author

L. Z. Penn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

J. Longo· 2 shared A. Ahlner· 1 shared A. Lemak· 1 shared A. Tamachi· 1 shared A.-C. Gingras· 1 shared B. Wallner· 1 shared C. H. Arrowsmith· 1 shared C. Lourenco· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

J. Longo

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Author profile →

3 papers

Recent·Most cited

SLC3A2 N-glycosylation and alternate evolutionary trajectories for amino acid metabolism

C. Zhang, M. Shafaq-Zadah, J. Pawling, G. G. Hesketh, D. Ng, E. Dransart, K. Pacholczyk, J. Longo, A.-C. Gingras, L. Z. Penn, L. Johannes, J. W. Dennis

This study investigates how N-glycosylation sites on SLC3A2 evolve and regulate amino acid transport and redox balance, revealing their role in cellular trafficking and bird evolution.

bioRxiv · Nov 15, 2022 · PreprintCell Biology

The PNUTS-PAD domain recruits MYC to the PNUTS:PP1 phosphatase complex via the oncogenic MYC-MB0 region

Y. Wei, A. Ahlner, C. Redel, A. Lemak, I. Johansson-Akhe, S. Houliston, T. M. G. Kenney, A. Tamachi, V. Morad, S. Duan, D. W. Andrews, B. Wallner, M. Sunnerhagen, C. H. Arrowsmith, L. Z. Penn

This paper identifies the MB0 region of MYC as a direct binder to the PNUTS amino-terminal domain (PAD), revealing a molecular mechanism for MYC regulation by the PNUTS:PP1 phosphatase complex.

bioRxiv · Dec 2, 2021Cancer Biology

Modeling the MYC-driven normal-to-tumour switch in breast cancer.

C. Lourenco, M. Kalkat, K. E. Houlahan, J. De Melo, J. Longo, S. J. Done, P. C. Boutros, L. Z. Penn

This study creates an in vivo model of MYC-driven breast cancer by combining PIK3CAH1047R mutation with deregulated MYC, showing a normal-to-tumour switch and dependence on MYC for tumor growth.

bioRxiv · Aug 20, 2018Cancer Biology