R. B. West

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity

This study uses scRNA-seq to analyze DCIS and normal breast tissue, identifying clonal heterogeneity and cell state changes associated with progression to invasive cancer.

Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.

The paper analyzes molecular differences in ductal carcinoma in situ (DCIS) by self-reported race and outcome groups, identifying variations in gene expression, tumor microenvironment, and copy number variations between Black and White women.

Cholangiocytic differentiation drives cell proliferation in hepatoblastoma through Wnt-dependent FGF19 signaling

The paper identifies FGF19 as a paracrine signal driving tumor growth in hepatoblastoma through Wnt-dependent mechanisms and biliary lineage activation.

Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity

This study shows germline variants influence somatic evolution in breast cancer by modulating immunoediting, affecting tumor subtype and metastatic potential.

A spatial map of human macrophage niches links tissue location with function

The paper identifies distinct macrophage niches in human breast and colon tissues using single-cell RNA sequencing and imaging, linking their spatial distribution to functional roles.

Collective invasion of the basement membrane in breast cancer driven by forces from cell volume expansion and local contractility

This study shows breast cancer cells invade the basement membrane using both proteases and mechanical forces from cell volume expansion and local contractility.

Interactions in CSF1-driven Tenosynovial Giant Cell Tumors

The paper identifies GFPT2 as a marker for synoviocytes in TGCT and shows neoplastic cells lack CSF1R, suggesting current therapies may not target them effectively.

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma

The paper analyzes tumor microenvironment changes from normal to invasive breast cancer using imaging and machine learning, finding coordinated shifts in stromal cell location and function.

Unmasking the tissue microecology of ductal carcinoma in situ with deep learning

This paper develops a deep learning pipeline to detect and segment DCIS ducts, revealing that pure DCIS has more TILs but less co-localization with ducts compared to adjacent DCIS.

YAP-independent mechanotransduction drives breast cancer progression

This study shows that mechanotransduction in breast cancer occurs without YAP, due to compact nuclear morphologies in vivo.