Author

K. E. Lyke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. A. Berry· 3 shared A. Dembele· 2 shared A. H. Idris· 2 shared A. K. Kone· 2 shared A. Niangaly· 2 shared B. Kouriba· 2 shared C. V. Plowe· 2 shared D. Coulibaly· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMicrobiology

A. A. Berry

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Gene expression analyses reveal differences in children's response to malaria according to their age

K. Tebben, S. Yirampo, D. Coulibaly, A. K. Kone, M. B. Laurens, E. Stucke, A. Dembele, Y. Tolo, K. Traore, A. Niangaly, A. A. Berry, B. Kouriba, C. V. Plowe, K. E. Lyke, S. Takala-Harrison, , D. Serre

The paper examines how parasitemia and child age influence host and parasite gene expression in malaria infections, revealing age-dependent immune responses and parasite dynamics.

bioRxiv · Oct 24, 2023 · PreprintMicrobiology

Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles.

K. Tebben, S. Yirampo, D. Coulibaly, A. K. Kone, M. B. Laurens, E. Stucke, A. Dembele, Y. Tolo, K. Traore, A. Niangaly, A. A. Berry, B. Kouriba, C. V. Plowe, O. K. Doumbo, K. E. Lyke, , D. Serre

The paper compares gene expression profiles in Malian children infected with Plasmodium falciparum and P. ovale, finding similar host immune responses but distinct parasite gene expression.

bioRxiv · Sep 9, 2022Microbiology

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

H. J. Sutton, R. Aye, A. H. Idris, R. Vistein, E. Nduati, O. Kai, J. Mwacharo, L. Xi, X. Gao, D. Andrews, M. Koutsakos, T. H. O. Nguyen, M. Nekrasov, P. Milburn, A. Ethala, , I. A. Cockburn

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

bioRxiv · May 28, 2020 · PreprintImmunology

Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses

H. A. McNamara, A. H. Idris, H. J. Sutton, B. J. Flynn, Y. Cai, K. Wiehe, K. E. Lyke, D. Chatterjee, N. KC, S. Chakravarty, K. L. Sim, S. L. Hoffman, M. Bonsignori, R. A. Seder, I. A. Cockburn

The paper shows antibody feedback limits memory B cell expansion but allows diversification of vaccine-induced antibody responses by suppressing dominant epitopes while enabling subdominant ones.

bioRxiv · Oct 18, 2019 · PreprintImmunology