M. Koutsakos

Dissemination of influenza B virus to the lower respiratory tract of mice is restricted by the interferon response

This study shows that influenza B virus dissemination from the upper respiratory tract to the lungs in mice is restricted by the interferon response and that TRT priming provides better protection than URT priming.

Differential cross-reactivity to the influenza B virus haemagglutinin underpins lineage-specific susceptibility between birth cohorts

The paper shows that early life exposure to influenza B virus influences cross-reactivity and susceptibility to future isolates, explaining lineage-specific infection patterns across birth cohorts.

Rapid recall and de novo T cell responses during SARS-CoV-2 breakthrough infection

This study examines T cell responses during SARS-CoV-2 breakthrough infections, showing rapid recall of memory T cells and a correlation between CD8+ T cell activation and viral clearance.

High expression of CD38 and MHC class II on CD8+ T cells during severe influenza disease reflects bystander activation and trogocytosis

This study investigates CD38 and MHC-II co-expression on CD8+ T cells during severe influenza, finding that it reflects bystander activation and trogocytosis from antigen-presenting cells, and is important for memory establishment.

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

MAIT cells contribute to protection against lethal influenza infection in vivo

This study shows MAIT cells protect against lethal influenza infection by accumulating and being activated early, with their absence increasing mortality in mice.