Author

K. L. Sim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

S. L. Hoffman· 3 shared S. Chakravarty· 2 shared A. Chokkathukalam· 1 shared A. H. Idris· 1 shared A. Obraztsova· 1 shared B. J. Flynn· 1 shared B. Mordmueller· 1 shared D. A. Fidock· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

S. L. Hoffman

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Author profile →

3 papers

Recent·Most cited

Clonal evolution and specificity of the human T follicular helper cell response to Plasmodium falciparum circumsporozoite protein

I. Wahl, A. Obraztsova, J. Puchan, R. Hundsdorfer, S. Chakravarty, K. L. Sim, S. L. Hoffman, P. Kremsner, B. Mordmueller, H. Wardemann

This study examines the clonal evolution and TCR specificity of human TFH cells responding to PfCSP during malaria immunization, revealing HLA restrictions and epitope-specific dynamics.

bioRxiv · Sep 10, 2021 · PreprintImmunology

Lipoic acid biosynthesis is essential for Plasmodium falciparum transmission and influences redox response and carbon metabolism of parasite asexual blood stages

M. Biddau, S. T. R. Kumar, P. Henrich, L. M. Laine, G. J. Blackburn, A. Chokkathukalam, T. B. Li, K. L. Sim, S. L. Hoffman, M. P. Barrett, G. H. Coombs, G. I. McFadden, D. A. Fidock, S. Muller, L. Sheiner

bioRxiv · May 17, 2020 · PreprintCell Biology

Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses

H. A. McNamara, A. H. Idris, H. J. Sutton, B. J. Flynn, Y. Cai, K. Wiehe, K. E. Lyke, D. Chatterjee, N. KC, S. Chakravarty, K. L. Sim, S. L. Hoffman, M. Bonsignori, R. A. Seder, I. A. Cockburn

The paper shows antibody feedback limits memory B cell expansion but allows diversification of vaccine-induced antibody responses by suppressing dominant epitopes while enabling subdominant ones.

bioRxiv · Oct 18, 2019 · PreprintImmunology