Author

A. J. Armstrong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Microbiology· 2 Ecology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 7 Organism:human· 6 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:metagenomics· 2

Frequent Co-Authors

J. A. Somarelli· 4 shared K. E. Ware· 4 shared M. K. Jolly· 4 shared W. C. Eward· 3 shared B. C. Thomas· 2 shared B. E. Palmer· 2 shared C. A. Lozupone· 2 shared D. Runyambo· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersCancer Biology

J. A. Somarelli

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Toxicogenomic analysis of the carcinogenic potential of plastic additives

S. Vincoff, B. Schleupner, J. Santos, M. Morrison, N. Zhang, M. M. Dunphy-Daly, W. C. Eward, A. J. Armstrong, Z. Diana, J. Somarelli

This study analyzes the carcinogenic potential of 2,712 plastic additives using toxicogenomic methods, finding over 150 known carcinogens and most lacking carcinogenicity data.

bioRxiv · Jun 30, 2023 · PreprintPharmacology & Toxicology

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

K. E. Ware, B. C. Thomas, P. Olawuni, M. U. Sheth, N. Hawkey, Y. M, B. C. Miller, K. Vietor, M. K. Jolly, S. Y. Kim, A. J. Armstrong, J. A. Somarelli

The paper identifies JAK/STAT signaling as a therapeutic target for Snail-induced enzalutamide-resistant prostate cancer through synthetic lethal screens and validation in a resistant cell model.

bioRxiv · Nov 15, 2022Cancer Biology

Analysis of immune subtypes across the epithelial-mesenchymal plasticity spectrum

P. Chakraborty, E. Chen, I. McMullen, A. J. Armstrong, M. K. Jolly, J. A. Somarelli

The paper analyzes immune subtypes across the epithelial-mesenchymal plasticity spectrum in cancers, finding heterogeneity in EMT status and associations between immune subtypes and EMT scores.

bioRxiv · Mar 22, 2021Cancer Biology

Systems analysis of gut microbiome influence on metabolic disease in HIV and high-risk populations

A. J. Armstrong, K. Quinn, J. Fouquier, S. X. Li, J. M. Schneider, N. M. Nusbacher, K. A. Doenges, S. Fiorillo, T. J. Marden, J. Higgins, N. Reisdorph, T. B. Campbell, B. E. Palmer, C. A. Lozupone

The paper investigates the relationship between gut microbiome, metabolic health, and inflammation in HIV-positive and high-risk men who have sex with men, finding that elevated lipopolysaccharide binding protein (LBP) is a key predictor of metabolic disease.

bioRxiv · Mar 12, 2021Microbiology

Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes

K. E. Ware, S. Gupta, J. Eng, G. Kemeny, B. J. Puviindran, W.-C. Foo, L. A. Crawford, R. G. Almquist, D. Runyambo, B. C. Thomas, M. U. Sheth, A. Agarwal, M. Pierobon, E. F. Petricoin, D. L. Corcoran, , J. Somarelli

This study identifies p38/MAPK pathway activation as a convergent mechanism driving survival, immune evasion, and metastasis in hormone-resistant prostate cancer.

bioRxiv · Apr 22, 2020 · PreprintCancer Biology

The geographic distribution of reef and oceanic manta rays in the south-east Indian and south-west Pacific Oceans

A. J. Armstrong, A. O. Armstrong, M. B. Bennett, F. McGregor, K. G. Abrantes, A. Barnett, A. J. Richardson, K. A. Townsend, C. L. Dudgeon

This study maps the geographic distribution of two manta ray species in the south-east Indian and south-west Pacific Oceans using sighting records from various sources.

bioRxiv · Aug 6, 2019 · PreprintEcology

E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms

M. K. Jolly, K. E. Ware, S. Xu, S. Gilja, S. Shetler, Y. Yang, X. Wang, G. Austin, D. Runyambo, A. J. Hish, S. Bartholf DeWitt, J. T. George, R. T. Kreulen, M.-K. Boss, A. L. Lazarides, , J. A. Somarelli

This study identifies E-cadherin's role in suppressing sarcoma growth through both signaling (inhibiting p-CREB and TBX2) and mechanical (enhancing cell-cell adhesion) mechanisms.

bioRxiv · Jan 10, 2019Cancer Biology

An exploration of Prevotella-rich microbiomes in HIV and men who have sex with men

A. J. Armstrong, M. Shaffer, N. M. Nusbacher, C. Griesmer, S. Fiorillo, J. M. Schneider, C. P. Neff, S. X. Li, A. P. Fontenot, T. Campbell, B. E. Palmer, C. A. Lozupone

The paper examines microbiome differences in HIV-infected and uninfected men who have sex with men, identifying lifestyle, ART, and HIV-related factors influencing gut microbiota composition.

bioRxiv · Sep 23, 2018Microbiology

An integrative systems biology and experimental approach identifies convergence of epithelial plasticity, metabolism, and autophagy to promote chemoresistance

S. Xu, K. E. Ware, Y. Ding, S. Y. Kim, M. Sheth, S. Rao, W. Chan, A. J. Armstrong, W. C. Eward, M. K. Jolly, J. A. Somarelli

bioRxiv · Jul 10, 2018Cancer Biology