Z. Tong

Blockade of TREM2 ameliorates pulmonary inflammation and fibrosis by modulating sphingolipid metabolism

This study shows that blocking TREM2 reduces pulmonary inflammation and fibrosis by altering sphingolipid metabolism and chemokine expression in macrophages.

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

ARF6-dependent endocytic trafficking of the Interferon-γ receptor drives adaptive immune resistance in cancer.

This study identifies ARF6-dependent endocytic trafficking of the IFN-gamma receptor as a mechanism driving adaptive immune resistance in cancer, linking it to immune checkpoint blockade efficacy.

Structural Visualization of HECT-type E3 ligase Ufd4 Accepting and Transferring Ubiquitin to Form K29/K48-branched Polyubiquitination

This study determines the structural mechanism of HECT-type E3 ligase Ufd4 in catalyzing K29/K48-branched polyubiquitination by capturing structural snapshots of Ub transfer cascades.

Ralstonia solanacearum effector RipAF1 ADP-ribosylates host FBN1 to induce resistance against bacterial wilt

This study identifies RipAF1 as an effector that ADP-ribosylates host FBN1, inducing resistance against bacterial wilt by disrupting disease signaling.

Intratumoral Delivered Novel Circular mRNA Encoding Cytokines for Immune Modulation and Cancer Therapy

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

Low antigen abundance limits efficient T-cell recognition of highly conserved regions of SARS-CoV-2

The paper identifies conserved T-cell epitopes in SARS-CoV-2 and finds that immune responses against them are subdominant due to low antigen abundance.

Reversion of antibiotic resistance in drug-resistant bacteria using non-steroidal anti-inflammatory drug benzydamine

This study shows benzydamine enhances tetracycline antibiotics' effectiveness against drug-resistant bacteria by disrupting membrane potential and increasing drug uptake.

Identifying Upper Airway and Evaluating Adenoid in Lateral Cephalometric Radiographs of Pediatric Patients Using Image-based Deep Learning Technique

This paper develops a deep learning system to assess upper airway obstruction and adenoid size in pediatric radiographs, achieving good segmentation performance and agreement with experts.

Brucella outer membrane proteins to control maturation and antigen presentation of mouse dendritic cells

This study examines how Brucella outer membrane proteins and mutants affect dendritic cell maturation and antigen presentation in mice, revealing their roles in immune evasion and pathogenesis.

Myofibrillar Structural Variability Underlies Contractile Function in Stem Cell-Derived Cardiomyocytes

This study shows myofibrillar structure variability in iPSC-derived cardiomyocytes affects contractile function and should be considered in disease modeling and drug testing.

Unravel the Mystery of NIC1-locus on Nicotine Biosynthesis Regulation in Tobacco

This paper identifies and characterizes the NIC1-locus in tobacco, showing it regulates nicotine biosynthesis through ERF genes that function downstream of NtMYC2 in the JA signaling pathway.

Broad-Spectrum Antifungal Activities and Mechanism of Drimane Sesquiterpenoids

This study synthesizes and evaluates drimane sesquiterpenoids for antifungal activity, identifying drimenol as a broad-spectrum antifungal agent effective against multiple fungal species and resistant strains.

Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice

This study shows that BMP9 protects pulmonary endothelium during inflammation-induced lung injury and that exogenous BMP9 can prevent lung injury in mice.

Preserving Vascular Integrity Protects Mice Against Multidrug-Resistant Gram-Negative Bacterial Infection

This study shows that inhibiting ARF6 protects mice from MDR Gram-negative bacterial infections by preserving vascular integrity.

Compressive Stress Enhances Invasive Phenotype of Cancer Cells via Piezo1 Activation

This study shows compressive stress enhances breast cancer cell invasion via Piezo1 activation, leading to increased matrix degradation and invadopodia formation.