This study challenges the idea that HSC numbers are solely determined by niche availability, showing systemic and local constraints on HSC numbers regardless of niche changes.

bioRxiv · Oct 28, 2023 · PreprintCell Biology

NG2+/Nestin+ mesenchymal stem cells dictate DTC dormancy in the bone marrow through TGFβ2

A. R. Nobre, E. Risson, D. K. Singh, J. S. Di Martino, J. F. Cheung, J. Wang, J. Johnson, H. G. Russnes, J. J. Bravo-Cordero, A. Birbrair, B. Naume, M. Azhar, P. S. Frenette, J. A. Aguirre-Ghiso

This study shows NG2+/Nestin+ mesenchymal stem cells in the bone marrow use TGFβ2 to induce dormancy in breast cancer disseminated tumor cells.

bioRxiv · Oct 22, 2020Cancer Biology

Hematopoietic stem cells fail to regenerate following inflammatory challenge.

R. Bogeska, P. Kaschutnig, M. Fawaz, A.-M. Mikecin, M. Buechler-Schaeff, S. Paffenholz, N. Asada, F. Frauhammer, F. Buettner, M. Ball, J. Knoch, S. Staeble, D. Walter, A. Petri, M. J. Carreno-Gonzalez, , M. D. Milsom

This study shows that repeated inflammatory challenges lead to progressive depletion of functional HSCs with no recovery, contributing to age-related hematopoietic decline.

bioRxiv · Aug 1, 2020Cell Biology

Dietary intake regulates the circulating inflammatory monocyte pool

S. Jordan, N. Tung, M. Casanova-Acebes, C. Chang, C. Cantoni, D. Zhang, T. H. Wirtz, S. Naik, S. A. Rose, C. N. Brocker, A. Gainullina, B. B. Maier, D. LeRoith, F. J. Gonzalez, F. Meissner, , M. Merad

This study shows that fasting reduces circulating pro-inflammatory monocytes and their metabolic activity, while preserving their emergency mobilization during acute inflammation.

bioRxiv · Mar 21, 2019Immunology