K. Gupta

This study shows that altering Phe80 in PAH affects its conformational equilibrium, revealing intermediates in the transition between resting and activated states.

This study shows that prior radiation therapy promotes tumor aggressiveness in glioblastoma by inducing metabolic changes that create a protumorigenic microenvironment.

This study characterizes the structure of tau in fuzzy tau:tubulin complexes using fluorophore probes and compares it to cryo-EM models of tau:MT complexes.

This study shows that BAK/BAX spontaneous oligomerization is suppressed by MCL-1 hetero-dimerization, with BH3-only proteins disrupting these interactions to promote apoptosis.

The paper links placental invasion and cancer metastasis by showing that human stromal cells are more permissive to invasion than bovine cells, supporting the Evolved Levels of Invasibility hypothesis.

The paper introduces a sequential digestion method using trypsin and elastase to improve cross-linking/mass spectrometry analysis of protein complexes by accessing previously inaccessible regions.

The paper shows bile canaliculi contract by releasing calcium into hepatocytes via mechanosensitive channels, driven by bile pressure and regulated by Piezo-1.

The paper models the dynamics of intercellular secretory lumen formation, predicting a critical pumping threshold and a transition between monotonous and oscillatory regimes during luminogenesis.

The paper identifies a ternary TAF11/TAF13/TBP complex and reveals a novel regulatory state in TFIID function through structural and biochemical analyses.

The paper identifies SCFSlmb as a regulator of SMN protein stability through a degron, showing that self-oligomerization stabilizes SMN isoforms and mitigates SMA severity.