K. J. F. Satchell

Control of Biofilm Formation by an Agrobacterium tumefaciens Pterin-Binding Periplasmic Protein Conserved Among Pathogenic Bacteria

This paper identifies a pterin-responsive regulatory mechanism in Agrobacterium tumefaciens that controls biofilm formation through interactions between PruR, DcpA, and pterins.

Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy

This study identifies MCF, a Vibrio effector that cleaves and degrades Rab GTPases, disrupting organelle function and promoting cell death during infection.

Functional and Structural Characterization of OXA-935, a Novel OXA-10-family β-lactamase from Pseudomonas aeruginosa

This study identifies and characterizes OXA-935, a novel OXA-10-family β-lactamase from Pseudomonas aeruginosa, showing it confers ceftazidime resistance through specific amino acid substitutions.

RAS specific protease Induces Irreversible Growth Arrest via p27 in several KRAS Mutant Colorectal Cancer cell lines

This study shows that RRSP induces growth arrest in KRAS mutant colorectal cancer cells via p27, with varying cell fates depending on the cell line.

The Vibrio cholerae MARTX toxin simultaneously induces actin collapse while silencing the inflammatory response to cytoskeletal damage

This study shows that the Vibrio cholerae MARTX toxin suppresses inflammation by coordinating actin collapse and inhibiting MAPK signaling through its multiple effector domains.

N-terminal autoprocessing and acetylation of MARTX Makes-Caterpillars Floppy-like effector is stimulated by ADP-Ribosylation Factor 1 in advance of Golgi fragmentation

This study identifies ARF1 and ARF3 as activators of MCF autoprocessing and shows that MCF acetylation and Golgi fragmentation contribute to cytotoxicity.