Author

J. H. Brumell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

O. Florey· 2 shared S. Grinstein· 2 shared T. Li· 2 shared A. Agrawal· 1 shared A. Ballabio· 1 shared A. Deiters· 1 shared A. Herrera· 1 shared A. Jha· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

O. Florey

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy

A. Herrera, M. M. Packer, M. Rosas-Lemus, G. Minasov, J. H. Brumell, K. J. F. Satchell

This study identifies MCF, a Vibrio effector that cleaves and degrades Rab GTPases, disrupting organelle function and promoting cell death during infection.

bioRxiv · Apr 19, 2023 · PreprintMicrobiology

Phosphatidylinositol 3-kinase-independent synthesis of PtdIns(3,4)P2 by a phosphotransferase

G. Walpole, J. Pacheco, N. Chauhan, Y. Abbas, F. Montano-Rendon, Z. Liu, H. Zhu, J. H. Brumell, A. Deiters, G. R. Hammond, S. Grinstein, G. D. Fairn

The paper shows that Salmonella and Shigella effectors generate PtdIns(3,4)P2 independently of phosphoinositide 3-kinases using a phosphotransferase mechanism.

bioRxiv · May 25, 2021 · PreprintCell Biology

V-ATPase is a universal regulator of LC3 associated phagocytosis and non-canonical autophagy

K. M. Hooper, E. Jacquin, T. Li, J. M. Goodwin, J. H. Brumell, J. Durgan, O. Florey

This study identifies V-ATPase as a universal regulator of LC3-associated phagocytosis and non-canonical autophagy, showing its role in CASM activation and its disruption by Salmonella SopF.

bioRxiv · May 20, 2021Cell Biology

GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis

J. Goodwin, W. G. Walkup, K. Hooper, T. Li, C. Kishi-Itakura, A. Ng, T. Lehmberg, A. Jha, S. Kommineni, K. Fletcher, J. Garcia-Fortanet, Y. Fan, Q. Tang, M. Wei, A. Agrawal, , L. O. Murphy

bioRxiv · Feb 22, 2021Cell Biology

Rab5 regulates macropinosome closure by recruitment of OCRL/Inpp5b and hydrolysis of PtdIns(4,5)P2

S. Grinstein, H. Sarantis, J. H. Brumell, A. Volchuk, M. Maxson

This study identifies Rab5's role in macropinosome closure by recruiting OCRL/Inpp5b and hydrolyzing PtdIns(4,5)P2.

bioRxiv · Jun 8, 2020 · PreprintCell Biology