K. Jung

A distant TANGO1 family member promotes vitellogenin export from the ER in C. elegans

This study identifies TNGL-1 as a C. elegans TANGO1 family member that facilitates vitellogenin export from the ER by engaging cargo via a luminal domain.

Direct RNA sequencing of the Escherichia coli epitranscriptome uncovers alterations under heat stress

This study uses direct RNA sequencing to analyze RNA modifications in E. coli under heat stress, revealing changes in m5C, m6A, and m6,6A levels in rRNA and shifts in mRNA modification patterns.

Adolescent maturation of cortical excitation-inhibition balance based on individualized biophysical network modeling

This study develops an individualized in vivo marker of excitation-inhibition balance in adolescents using biophysical network models and finds increased inhibition in association cortices during development.

Depletion of m6A-RNA in Escherichia coli reduces the infectious potential of T5 bacteriophage

This study shows that reducing m6A RNA levels in E. coli decreases T5 phage infection efficiency but not other phages.

The chemoreceptor controlling the Wsp-like transduction pathway in Halomonas titanicae KHS3 binds purine derivatives

This paper identifies purine derivatives as ligands for the chemoreceptor Htc10 in Halomonas titanicae, revealing its structure and binding specificity.

One to rule them all? Assessing the performance of sustainable forest management indicators against multitaxonomic data for biodiversity conservation

The paper evaluates Forest Europe biodiversity indicators against multitaxonomic data, finding no single indicator captures overall biodiversity, but combinations perform better.

Decrypting the functional design of unmodified translation elongation factor P

This study identifies unmodified EF-P variants from Rhodomicrobium vannielii that restore function in E. coli lacking EF-P modifications, revealing design principles for polyproline synthesis.

Dissecting Mechanisms of Ligand Binding and Conformational Changes in the Glutamine-Binding Protein

This study investigates the ligand binding mechanism of GlnBP in E. coli, finding that conformational changes and ligand binding are correlated, and that the induced-fit mechanism is more consistent with the data than conformational selection.

A fast-slow trait continuum at the level of entire communities

The paper shows that slow and fast functional strategies manifest at the ecosystem level, driven by disturbance and resource availability in grassland communities.

Rat hepatitis E virus (HEV) cross-species infection and transmission in pigs

This study investigates whether pigs can transmit rat HEV to other pigs, finding that an infectious clone of rat HEV replicates in vitro and infects pigs, which then transmit the virus to cohoused animals.

Ribosome profiling reveals the fine-tuned response of Escherichia coli to mild and severe acid stress

This study uses ribosome profiling and RNA sequencing to analyze E. coli's response to mild and severe acid stress, identifying new genes, pathways, and sORFs.

Urbanisation generates multiple trait syndromes for terrestrial taxa worldwide

This study shows urbanisation causes taxon-specific trait changes in terrestrial species, with reproductive and dietary traits most affected, and identifies four general urban trait syndromes.

VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

Identification of two pyruvate transporters in Salmonella enterica serovar Typhimurium and their biological relevance

This study identifies two pyruvate transporters in Salmonella Typhimurium and shows their roles in chemotaxis, stress survival, and infection.

Structural basis for mismatch surveillance by CRISPR/Cas9

This study identifies a linear gRNA:DNA duplex conformation that prevents Cas9 activation in the presence of PAM-distal mismatches, offering insights for improving Cas9 specificity.

Exploring the interaction network of a synthetic gut bacterial community

This study investigates the interaction network of a synthetic gut bacterial community, revealing exploitative and interference competition shaping community dynamics.

Dynamics of chromosomal target search by a membrane-integrated one-component receptor

This study investigates how a membrane-integrated one-component receptor, CadC, locates its DNA target through diffusion and capture mechanisms, revealing that DNA mobility is sufficient for efficient target search.

Designing Sub-20 nm Nanocarriers for Small Molecule Delivery: Interplay among Structural Geometry, Assembly Energetics, and Cargo Release Kinetics

This paper examines how structural geometry, assembly energetics, and cargo release kinetics interact in sub-20 nm nanocarriers, showing that small molecule compatibility and release behavior are influenced by these factors.

Assessing the impact of grassland management on landscape multifunctionality

This paper identifies optimal grassland compositions for ecosystem services using simulation and an online tool, showing that mixed intensity landscapes can maximize multifunctionality when services trade-off.

Sequential MAVS- and MyD88/TRIF-signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes

This study identifies astrocytes as key IFN-β producers in TBEV-infected mice, showing biphasic IFN-β induction dependent on MAVS and later MyD88/TRIF signaling.

Design of 18 nm Doxorubicin-loaded 3-helix Micelles: Cellular Uptake and Cytotoxicity in Patient-derived GBM6 Cells

Highly Sensitive Identification of Lymphatic and Hematogenous Metastasis Routes of Novel Radiolabeled Exosomes Using Non-invasive PET Imaging

This study labels exosomes with radiotracers and uses PET imaging to track their lymphatic and hematogenous metastasis routes in mice.

Papillary renal cell carcinomas rewire glutathione metabolism and are deficient in anabolic glucose synthesis

This study identifies metabolic reprogramming in papillary renal cell carcinomas, including increased glutathione synthesis and reduced anabolic glucose synthesis.

Metabolic reprogramming and elevation of glutathione in chromophobe renal cell carcinomas

This study identifies metabolic reprogramming and elevated glutathione in chromophobe renal cell carcinomas through multi-omics profiling.

Basis for discrimination by engineered CRISPR/Cas9 enzymes

This study investigates how engineered CRISPR/Cas9 variants improve off-target discrimination by analyzing their kinetic behavior during DNA cleavage.

Structural basis for EarP-mediated arginine glycosylation of translation elongation factor EF-P

The paper determines the crystal structure of EarP, revealing its mechanism for arginine glycosylation of EF-P and its role in bacterial pathogenicity.