Author

K. Bosch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Animal Behavior & Cognition· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:behavioral assay· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

A. A. Machado· 1 shared A. Delor· 1 shared A. Jeschko· 1 shared A. Marcu· 1 shared A. N. Weber· 1 shared A. Sorokin· 1 shared A. Tapia Abellan· 1 shared B. Grimbacher· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. A. Machado

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance

V. Thatikonda, H. Lu, S. Jurado, K. Kostyrko, C. A. Bristow, K. Bosch, N. Feng, S. Gao, D. Gerlach, M. Gerlach, S. Lieb, A. Jeschko, A. A. Machado, E. D. Marszalek, M. Mahendra, , M. H. Hofmann

This study shows that combining KRASG12C and SOS1 inhibitors improves anti-tumor response and delays resistance in KRASG12C-driven cancers.

bioRxiv · Jan 23, 2023Cancer Biology

BDNF Overexpression in the Prelimbic Cortex Does Not Reduce Anxiety- and Depression-like Behavior in Serotonin Knockout Rats

D. M. Diniz, K. Bosch, F. Calabrese, P. Brivio, M. A. Riva, J. Grandjean, J. R. Homberg

This study investigates whether BDNF overexpression in SERT-/- rats rescues anxiety- and depression-like behaviors, finding no rescue and HPA-axis dysfunction in wild-type rats.

bioRxiv · Jul 1, 2020 · PreprintAnimal Behavior & Cognition

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

Z. A. Bittner, X. Liu, S. Shankar, A. Tapia Abellan, H. Kalbacher, L. Andreeva, M. Mangan, P. Duewell, M. Lovotti, K. Bosch, S. Dickhoefer, A. Marcu, S. Stevanovic, F. Herster, M. W. Loeffler, , A. N. Weber

The paper shows BTK modulates NLRP3 inflammasome activity through phosphorylation of tyrosine residues, affecting localization, oligomerization, and IL-1β release.

bioRxiv · Jun 25, 2020Immunology