Author

E. W. Newell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 9 Organism:human· 7 Assay:scRNA-seq· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

M. J. McElrath· 3 shared y. SIMONI· 3 shared A. Talla· 2 shared D. S. W. TAN· 2 shared E. Becht· 2 shared E. M. Coffey· 2 shared F. Ginhoux· 2 shared H. MacMillan· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

M. J. McElrath

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Author profile →

9 papers

Recent·Most cited

Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge

D. A. Oyong, F. J. Duffy, M. L. Neal, Y. Du, J. Carnes, K. V. Schwedhelm, N. Hertoghs, S.-H. Jun, H. Miller, J. D. Aitchison, S. C. De Rosa, E. W. Newell, M. J. McElrath, S. M. McDermott, K. D. Stuart

The paper identifies distinct immune responses associated with vaccination status and protection outcomes after malaria challenge using transcriptome and cellular profiling.

bioRxiv · Dec 9, 2022 · PreprintImmunology

Persistent serum protein signatures define an inflammatory subset of long COVID

A. Talla, S. V. Vasaikar, G. Szeto, M. P. Lemos, J. L. Czartoski, H. MacMillan, Z. Moodie, K. W. Cohen, L. B. Fleming, Z. Thomson, L. Okada, L. A. Becker, E. M. Coffey, S. C. DeRosa, E. W. Newell, , T. R. Torgerson

Serum proteome profiling identifies subsets of long COVID patients with evidence of persistent inflammation and key immune signaling pathways.

bioRxiv · May 9, 2022 · PreprintImmunology

Longitudinal immune dynamics of mild COVID-19 define signatures of recovery and persistence

A. Talla, S. V. Vasaikar, M. P. Lemos, Z. Moodie, M.-P. L. Pebworth, K. E. Henderson, K. W. Cohen, J. L. Czartoski, L. Lai, M. S. Suthar, A. T. Heubeck, P. C. Genge, C. R. Roll, M. Weiss, J. Reading, , T. F. Bumol

The paper profiles longitudinal immune responses in mild COVID-19 patients to identify recovery and persistence signatures.

bioRxiv · May 26, 2021 · PreprintImmunology

CD8+ T cell responses in convalescent COVID-19 individuals target epitopes from the entireSARS-CoV-2 proteome and show kinetics of early differentiation

H. Kared, A. D. Redd, E. M. Bloch, T. S. Bonny, H. Sumatoh, F. Kairi, D. Carbajo, B. Abel, E. W. Newell, M. P. Bettinotti, S. E. Benner, E. U. Patel, K. Littlefield, O. Laeyendecker, S. Shoham, , T. C. Quinn

The paper identifies CD8+ T cell epitopes across the SARS-CoV-2 proteome in convalescent individuals and shows their differentiation kinetics and correlation with immune markers.

bioRxiv · Oct 8, 2020 · PreprintImmunology

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

y. SIMONI, S. LI, S. ZHUANG, A. HEIT, S.-L. KOO, I.-T. CHOW, W. W. KWOK, I. B. TAN, D. S. W. TAN, E. W. NEWELL

The paper identifies bystander CD4+ T cells in human tumors, showing they are phenotypically distinct and express CD39, correlating with CD8+ TILs specific for non-cancer antigens.

bioRxiv · Jul 15, 2020 · PreprintImmunology

Infinity Flow: High-throughput single-cell quantification of 100s of proteins using conventional flow cytometry and machine learning

E. Becht, D. Tolstrup, C.-A. Dutertre, F. Ginhoux, E. W. Newell, R. Gottardo, M. B. Headley

Infinity Flow uses flow cytometry and machine learning to analyze hundreds of proteins across millions of cells, revealing novel lung cellular heterogeneity in melanoma metastasis models.

bioRxiv · Jun 17, 2020Immunology

A targeted multi-omic analysis approach measures protein expression and low abundance transcripts on the single cell level

F. Mair, J. R. Erickson, V. Voillet, Y. Simoni, T. Bi, A. J. Tyznik, J. Martin, R. Gottardo, E. W. Newell, M. Prlic

The paper introduces a targeted multi-omic approach that measures protein and low abundance transcript expression on single cells, requiring less sequencing depth than whole transcriptome methods.

bioRxiv · Jul 14, 2019Immunology

Partial absence of PD-1 expression by tumor-specific CD8+ T cells in EBV-driven lymphoepithelioma-like carcinoma: a case report

Y. SIMONI, E. Becht, S. Li, C. Y. LOH, J. P. S. YEONG, T. K. H. LIM, A. TAKANO, D. S. W. TAN, E. W. NEWELL

This study reports the absence of PD-1 expression on EBV-specific CD8+ T cells in LELC, suggesting anti-PD1/PD-L1 therapy may not be effective for this cancer type.

bioRxiv · Jul 9, 2019 · PreprintCancer Biology

A rule-based data-informed cellular consensus map of the human mononuclear phagocyte cell space

P. Guenther, B. Cirovic, K. Bassler, K. Haendler, M. Becker, C. A. Dutertre, V. Bigley, E. W. Newell, M. Collin, F. Ginhoux, A. Schlitzer, J. L. Schultze

The paper develops a rule-based data-informed approach to create a consensus map of the human mononuclear phagocyte cell space using computational integration and single-cell RNA-sequencing.

bioRxiv · Jun 3, 2019 · PreprintImmunology