Author

H. Sakurai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:cell-cell communication· 3 Research Focus:clustering· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J.-i. Suehiro· 2 shared Y. T. Matsunaga· 2 shared A. Bancaud· 1 shared D. Alcaide· 1 shared D. Shimojo· 1 shared H. Okano· 1 shared H. Oshima· 1 shared J. Cacheux· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

J.-i. Suehiro

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clusters

Y. Ikeda, J.-i. Suehiro, H. Oshima, S. Y. Kok, K. Takahashi, H. Sakurai, T. Watabe, M. Oshima, Y. T. Matsunaga

This study develops a 3D in vitro system to visualize tumor intravasation of CTC clusters and identifies TGF-β and activin signaling as essential for this process.

bioRxiv · Feb 28, 2024 · PreprintCancer Biology

Ultra-Rapid and Specific Gelation of Collagen Molecules for Transparent and Tough Gels by Transition Metal Complexation

T. Suezawa, N. Sasaki, N. Assan, Y. Uetake, K. Onuma, H. Sakurai, R. Katayama, M. Inoue, M. Matsusaki

This paper develops a method to rapidly form transparent and tough collagen gels using transition metal complexation, enabling deep-live cell observation in a mechanically tunable environment.

bioRxiv · Mar 21, 2023Bioengineering

Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport

J. Cacheux, A. Bancaud, D. Alcaide, J.-i. Suehiro, Y. Akimoto, H. Sakurai, Y. T. Matsunaga

This study shows that intraluminal pressure increases paracellular solute transport in endothelial tissues by causing structural remodeling and thinning of junctions.

bioRxiv · Jan 24, 2023Biophysics

Hit-and-run silencing of endogenous DUX4 by targeting DNA hypomethylation on D4Z4 repeats in facioscapulohumeral muscular dystrophy

M. Sasaki-Honda, T. Jonouchi, M. Arai, J. He, K. Okita, S. Sakurai, T. Yamamoto, H. Sakurai

This study uses hit-and-run silencing to suppress DUX4 in FSHD patient-derived iPSCs by targeting DNA hypomethylation on D4Z4 repeats, achieving sustained suppression for at least two weeks.

bioRxiv · Apr 12, 2022 · PreprintPathology

Skeletal muscle releases extracellular vesicles with distinct protein and miRNA signatures that accumulate and function within the muscle microenvironment

S. Watanabe, Y. Sudo, S. Kimura, K. Tomita, M. Noguchi, H. Sakurai, M. Shimizu, Y. Takahashi, R. Sato, Y. Yamauchi

This study identifies markers for skeletal muscle-derived extracellular vesicles (SkM-EVs) and shows they mainly function within the muscle microenvironment rather than contributing significantly to plasma EVs.

bioRxiv · Nov 30, 2021Physiology

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling

R. Muhammad Irfanur, T. Ito, D. Shimojo, K. Arimoto, K. Onodera, R. Okada, T. Nagashima, K. Yamamoto, Z. Khatun, H. Okano, H. Sakurai, K. Shimizu, M. Doyu, Y. Okada

This study develops a bulk differentiation method for MYOD1-hiPSCs to generate contractile skeletal muscles, improving efficiency and reducing clonal variation compared to clonal methods.

bioRxiv · Nov 22, 2021 · PreprintCell Biology