Author

K. R. Kranc

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. S. M. Magee· 1 shared B. Göttgens· 1 shared B. J. P. Huntly· 1 shared C. Mappereley· 1 shared C. Philippe· 1 shared D. O'Carroll· 1 shared F. Severi· 1 shared G. Giotopoulos· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. S. M. Magee

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A time and single-cell resolved model of hematopoiesis

I. Kucinski, J. Campos, M. Barile, F. Severi, N. Bohin, P. N. Moreira, L. Allen, H. Lawson, M. L. R. Haltalli, S. J. Kinston, D. O'Carroll, K. R. Kranc, B. Göttgens

The paper builds a real-time, quantitative model of hematopoiesis using time-series single-cell RNA-Seq and persistent labeling, revealing lineage-specific self-renewal and differentiation properties.

bioRxiv · Sep 7, 2022 · PreprintCell Biology

Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death.

K. Woodley, L. S. Dillingh, G. Giotopoulos, P. Madrigal, K. M. Rattigan, C. Philippe, V. Dembitz, A. S. M. Magee, R. Asby, L. N. van de Lagemaat, C. Mappereley, S. C. James, J. H. Prehn, K. Tzelepis, K. Rouault-Pierre, , P. Gallipoli

This study shows that inhibiting mannose metabolism sensitizes AML cells to cytarabine and FLT3 inhibitors by promoting ferroptotic cell death through fatty acid metabolism changes.

bioRxiv · May 16, 2022Cancer Biology