Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to GDNF secretion
L. Yang, Z. Lin, R. Mu, W. Wu, H. Zhi, X. Liu, H. Yang, L. Liu
This study shows neurons enhance blood-brain barrier function by increasing claudin-5 and VE-cadherin via GDNF secretion and develops a triple co-culture model to predict BBB permeability.
bioRxiv · Feb 7, 2024Cell Biology