Author

K. Shamim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Simeonov· 2 shared C. Z. Chen· 2 shared M. Xu· 2 shared W. Huang· 2 shared W. Zheng· 2 shared B. N. Tran· 1 shared C. Austin· 1 shared C. Klumpp-Thomas· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

A. Simeonov

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2 papers

Recent·Most cited

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

R. Huang, M. Xu, H. Zhu, C. Z. Chen, E. Lee, S. He, K. Shamim, D. Bougie, W. Huang, M. Hall, D. Lo, A. Simeonov, C. Austin, X. Qiu, H. Tang, W. Zheng

This paper develops a biological activity-based modeling approach to identify novel antiviral compounds against SARS-CoV-2 with high hit rates in live virus assays.

bioRxiv · Jul 27, 2020Cell Biology

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

K. Gorshkov, C. Z. Chen, R. Bostwick, L. Rasmussen, M. Xu, M. Pradhan, B. N. Tran, W. Zhu, K. Shamim, W. Huang, X. Hu, M. Shen, C. Klumpp-Thomas, Z. Itkin, P. Shinn, , W. Zheng

The paper identifies six autophagy modulators that block SARS-CoV-2 cytopathic effects in Vero-E6 cells with EC50 values between 2.0 and 13 µM.

bioRxiv · May 16, 2020Pharmacology & Toxicology