S. N. Savvides

Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

This study identifies AGR2 as a chaperone that regulates IRE1β activity in goblet cells by preventing its dimerization and endonuclease activity.

Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)

This study reveals the structural basis of IL-9 signaling and antagonism through crystallography and NMR, showing how IL-9 binds its receptor and how antibodies block its activity.

Unexpected Complexity of the Ammonia Monooxygenase in Archaea

The paper identifies two new subunits, AmoY and AmoZ, in the ammonia monooxygenase of ammonia oxidizing archaea, revealing structural and functional complexity.

Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein (IL-18BP) in inflammation and tumor immunity

This paper determines the crystal structure of the human IL-18:IL-18BP complex, revealing the molecular mechanism of IL-18 sequestration and identifying a higher-order 2:2 assembly with enhanced activity restraint.

CRISPR-SID: identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping

This paper introduces CRISPR-SID, a method to identify tumor dependencies in Xenopus models, revealing EZH2 as a druggable target for desmoid tumors.

The TPLATE subunit is essential for structural assembly of the endocytic TSET complex

The paper determines the structural architecture of the plant TSET complex and identifies key interactions essential for its assembly and function in endocytosis.

Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding.

This study identifies distinct lipid and protein binding roles of EH domains in the TPLATE complex, revealing their functional contributions to plant clathrin-mediated endocytosis.

The GspLM inner membrane complex from the bacterial type II secretion system is a dimer of dimers and interacts with the system ATPase with high affinity

This study characterizes the GspLM complex of the T2SS as a dimer of dimers that binds the ATPase GspE with high affinity, suggesting its role in T2SS biogenesis.

Sensory neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering

This study shows that mutations in ATL3 cause aberrant ER membrane tethering, disrupting ER network organization and contributing to sensory neuropathy.