Author

M. van de Rijn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Assay:imaging· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 2

Frequent Co-Authors

D. R. C. Colburg· 2 shared E. Forgo· 2 shared G. W. Charville· 2 shared M. Matusiak· 2 shared R. B. West· 2 shared S. Varma· 2 shared A. Azizi· 1 shared A. Baranski· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

D. R. C. Colburg

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Author profile →

6 papers

Recent·Most cited

A spatial map of human macrophage niches links tissue location with function

M. Matusiak, J. W. Hickey, B. Luca, G. Lu, L. Kidzinski, S. Shu, D. R. C. Colburg, D. J. Phillips, S. W. Brubaker, G. W. Charville, J. Shen, G. P. Nolan, A. M. Newman, R. B. West, M. van de Rijn

The paper identifies distinct macrophage niches in human breast and colon tissues using single-cell RNA sequencing and imaging, linking their spatial distribution to functional roles.

bioRxiv · Aug 18, 2022 · PreprintCancer Biology

Interactions in CSF1-driven Tenosynovial Giant Cell Tumors

D. G. P. van IJzendoorn, M. Matusiak, G. W. Charville, G. Spierenburg, S. Varma, D. R. C. Colburg, M. A. J. van de Sande, K. van Langevelde, D. G. Mohler, K. N. Ganjoo, N. Q. Bui, R. S. Avedian, J. V. M. G. Bovee, R. Steffner, R. B. West, M. van de Rijn

The paper identifies GFPT2 as a marker for synoviocytes in TGCT and shows neoplastic cells lack CSF1R, suggesting current therapies may not target them effectively.

bioRxiv · Jun 1, 2022Cancer Biology

A multiplexed in vivo approach to identify driver genes in small cell lung cancer

M. C. Lee, H. Cai, C. W. Murray, C. Li, Y. T. Shue, L. Andrejka, A. L. He, A. Holzem, A. P. Drainas, J. H. Ko, G. L. Coles, C. Kong, S. Zhu, C. Zhu, J. Wang, , J. Sage

The paper develops a multiplexed in vivo approach to identify driver genes in SCLC using CRISPR/Cas9 and lentiviral barcoding, finding TSC1 as a robust tumor suppressor.

bioRxiv · Mar 28, 2022Cancer Biology

CRISPR-SID: identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping

T. Naert, D. Tulkens, T. Van Nieuwenhuysen, J. Przybyl, S. Demuynck, M. van de Rijn, M. Al Jazrawe, B. Alman, P. J. Coucke, K. De Leeneer, C. Vanhove, S. N. Savvides, D. Creytens, K. Vleminckx

This paper introduces CRISPR-SID, a method to identify tumor dependencies in Xenopus models, revealing EZH2 as a druggable target for desmoid tumors.

Proceedings of the National Academy of Sciences · Nov 17, 2021Peer-reviewedCancer Biology

Multiplexed imaging of human tuberculosis granulomas uncovers immunoregulatory features conserved across tissue and blood

E. F. McCaffrey, M. Donato, L. Keren, Z. Chen, M. Fitzpatrick, V. Jojic, A. Delmastro, N. F. Greenwald, A. Baranski, W. Graf, M. Bosse, P. K. Ramdial, E. Forgo, D. Van Valen, M. van de Rijn, , M. Angelo

This study uses multiplexed imaging and transcriptomics to identify immunosuppressive features in TB granulomas and blood, linking local and systemic immune responses.

bioRxiv · Jun 8, 2020 · PreprintImmunology

Clinically-relevant cell type cross-talk identified from a human lung tumor microenvironment interactome

A. J. Gentles, A. Hui, W. Feng, A. Azizi, R. Nair, D. Knowles, A. Yu, Y. Jeong, A. Bejnood, E. Forgo, S. Varma, Y. Xu, A. Kuong, V. Nair, R. West, , S. Plevritis

The paper identifies clinically relevant cell type interactions in the lung tumor microenvironment using RNA-seq data from sorted cell populations.

bioRxiv · May 30, 2019 · PreprintCancer Biology