Author

L. Izzo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:metabolomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

S. Trefely· 3 shared C. Mesaros· 2 shared E. von Krusenstiern· 2 shared K. E. Wellen· 2 shared M. Noji· 2 shared N. W. Snyder· 2 shared A. Bostwick· 1 shared B. E. Schaffer· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

S. Trefely

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Author profile →

3 papers

Recent·Most cited

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

S. L. Campbell, C. Mesaros, L. Izzo, H. Affronti, T. Tsang, M. Noji, B. E. Schaffer, K. Sun, S. Trefely, S. Kruijning, J. Blenis, I. A. Blair, K. E. Wellen

This study shows that glutamine deprivation in pancreatic ductal adenocarcinoma cells increases free GlcNAc and activates NAGK-dependent hexosamine salvage to support tumor growth.

bioRxiv · Sep 13, 2020Cancer Biology

Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation

S. Trefely, K. Huber, J. Liu, M. Noji, S. Stransky, J. Singh, M. Doan, C. D. Lovell, E. von Krusenstiern, H. Jiang, A. Bostwick, H. L. Pepper, L. Izzo, S. Zhao, J. P. Xu, , N. W. Snyder

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.

bioRxiv · Jul 30, 2020 · PreprintBiochemistry

Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues

E. L. Varner, S. Trefely, D. Bartee, E. von Krusenstiern, L. Izzo, C. Bekeova, R. S. O'Connor, E. L. Seifert, K. Wellen, J. L. Meier, N. W. Snyder

This paper quantifies lactoyl-CoA in mammalian cells and tissues using LC-HRMS and provides a biosynthetic method for isotopically labeled lactoyl-CoA.

bioRxiv · Mar 15, 2020 · PreprintBiochemistry