Author

K.-P. Hopfner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:statistical model· 3 Organism:yeast· 3 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. Korber· 3 shared S. Eustermann· 3 shared A. Schmid· 2 shared E. Oberbeckmann· 2 shared M. Moldt· 2 shared V. Niebauer· 2 shared A. Ablasser· 1 shared A. Basu· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

P. Korber

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

N. Kessler, S. F. Viehmann, C. Krollmann, K. Mai, K. M. Kirschner, H. Luksch, P. Kotagiri, A. M. C. Boehner, D. Huugen, C. C. de Oliveira Mann, S. Otten, S. A. I. Weiss, T. Zillinger, K. Dobrikova, D. E. Jenne, , N. Garbi

This study identifies cGAS/STING/IFN-mediated nucleic acid sensing by monocyte-derived macrophages as a driver of severe pulmonary vasculitis and shows that targeting this pathway reduces disease severity.

bioRxiv · May 30, 2022Immunology

Sequence- and chemical specificity define the functional landscape of intrinsically disordered regions

I. Langstein-Skora, A. Schmid, F. Huth, D. Shabani, L. Spechtenhauser, M. Likhodeeva, F. Kunert, F. J. Metzner, R. J. Emenecker, M. O. G. Richardson, W. Aftab, M. J. Goetz, S. K. Payer, N. Pietrantoni, V. Sjenicic, , A. S. Holehouse

The paper investigates how sequence- and chemical specificity enable functional IDR diversity despite poor sequence conservation.

bioRxiv · Feb 10, 2022Biophysics

Genome information processing by the INO80 chromatin remodeler positions nucleosomes

E. Oberbeckmann, N. Krietenstein, V. Niebauer, Y. Wang, K. Schall, M. Moldt, T. Straub, R. Rohs, K.-P. Hopfner, P. Korber, S. Eustermann

This study identifies DNA shape/mechanics as key determinants for nucleosome positioning by the INO80 chromatin remodeler in yeast.

bioRxiv · Nov 3, 2020Biochemistry

Measuring DNA mechanics on the genome scale

A. Basu, D. G. Bobrovnikov, Z. Qureshi, T. Kayikcioglu, T. T. Ngo, A. Ranjan, S. Eustermann, B. Cieza, M. Hejna, T. H. Rube, K.-P. Hopfner, C. Wolberger, J. S. Song, T. Ha

This paper develops loop-seq to measure DNA bendability genome-wide and finds sequence-encoded low bendability upstream of TSSs that influences nucleosome positioning and chromatin remodeling.

bioRxiv · Aug 17, 2020Biophysics

Ruler elements in chromatin remodelers set nucleosome array spacing and phasing

E. Oberbeckmann, V. Niebauer, S. Watanabe, L. Farnung, M. Moldt, A. Schmid, P. Cramer, C. L. Peterson, S. Eustermann, K.-P. Hopfner, P. Korber

The paper identifies a ruler element in chromatin remodelers that determines nucleosome spacing and phasing in Saccharomyces cerevisiae.

bioRxiv · Feb 28, 2020Biochemistry