Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
Wesley H. Godfrey, Judy J. Lee, Shruthi Shanmukha, Kaho Cho, Xiaojing Deng, Chandrashekar R. Ambati, Vasanta Putluri, Abu Hena Mostafa Kamal, Paul M Kim, Nagireddy Putluri, Michael D. Kornberg
This study identifies phosphoglycerate mutase (PGAM) as a regulator of Treg differentiation through serine synthesis and one-carbon metabolism, showing its impact on immune suppression and autoimmunity.
eLife · Jan 30, 2025Peer-reviewedImmunology