Author

Payam Mohammad Gharibani

Johns Hopkins UniversityORCID 0000-0002-4546-0890Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Michael D. KornbergiD· 3 shared Efrat AbramsoniD· 2 shared Jingwen HuiD· 2 shared Matthew D. SmithiD· 2 shared Peter A. CalabresiiD· 2 shared Shruthi ShanmukhaiD· 2 shared Soonmyung A. HwangiD· 2 shared Wesley H. GodfreyiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Michael D. KornbergORCID

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3 papers

Recent·Most cited

Remodeling oligodendrocyte lipid metabolism via liver X receptors overcomes inflammatory blockade of remyelination

Judy J. Lee, Matthew D. Smith, Xiaojing Deng, Jingwen Hu, Andrew Love, Jerry S Jing, Payam Mohammad Gharibani, Pragney Deme, Abdulshakour Mohammadnia, Qiao‐Ling Cui, Daryan Chitsaz, Asmita Dhukhwa, Jaime Gonzalez Cardona, Kathryn C. Fitzgerald, Colleen T. Harrington, , Michael D. Kornberg

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

bioRxiv · Aug 15, 2026 · PreprintNeuroscience

PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination

Payam Mohammad Gharibani, Efrat Abramson, Shruthi Shanmukha, Matthew D. Smith, Wesley H. Godfrey, Judy J. Lee, Jingwen Hu, Maryna Baydyuk, Marie‐France Dorion, Xiaojing Deng, Yu Guo, Soonmyung A. Hwang, Jeffrey K. Huang, Peter A. Calabresi, Michael D. Kornberg, Paul M. Kim

The paper shows that bryostatin-1, a PKC modulator, shifts microglia and CNS macrophages from pro-inflammatory to regenerative states, promoting remyelination and neuroprotection in MS.

bioRxiv · Aug 28, 2023 · PreprintNeuroscience

Therapeutic Potential of Blocking GAPDH Nitrosylation with CGP3466b in Experimental Autoimmune Encephalomyelitis

Wesley H. Godfrey, Soonmyung A. Hwang, Kaho Cho, Shruthi Shanmukha, Payam Mohammad Gharibani, Efrat Abramson, Michael D. Kornberg

This study shows that blocking GAPDH nitrosylation with CGP3466b reduces neuroaxonal injury and disability in EAE, a model of multiple sclerosis, without affecting the immune system.

Frontiers in Neurology · Jan 24, 2023Peer-reviewedNeuroscience