NeurosciencebioRxivPreprint
PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination
Payam Mohammad Gharibani, Efrat Abramson, Shruthi Shanmukha…·Paul M. Kim
The paper shows that bryostatin-1, a PKC modulator, shifts microglia and CNS macrophages from pro-inflammatory to regenerative states, promoting remyelination and neuroprotection in MS.