Author

Karim Hussain

Institute of Cancer Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Charlotte E L Fisher· 1 shared Ciara Leonard-BookeriD· 1 shared Giulia MazzuccoiD· 1 shared Helder C. FerreiraiD· 1 shared Janie C OlveriD· 1 shared Mariya ShtumpfiD· 1 shared Max E. DouglasiD· 1 shared Peter SarkiesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Charlotte E L Fisher

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2 papers

Recent·Most cited

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1

Ciara Leonard-Booker, Giulia Mazzucco, Charlotte E L Fisher, Karim Hussain, Tom D Deegan, Ylli Doksani, Max E. Douglas

This study investigates how telomeres impede replication by showing G-rich DNA and shelterin subunit POT1 block lagging strand replication, with POT1 causing Okazaki fragment skipping and large single-stranded gaps.

The EMBO Journal · Jul 9, 2026Peer-reviewedMolecular Biology

ATRX safeguards cellular identity during C. elegans development

Janie C Olver, Mariya Shtumpf, Karim Hussain, Stephen P. Methot, Peter Sarkies, Helder C. Ferreira

This study shows that XNP-1, the C. elegans homologue of ATRX, maintains cellular identity by preventing ectopic germline gene expression, and its loss leads to developmental defects.

bioRxiv · Mar 11, 2025 · PreprintMolecular Biology