Ylli Doksani

DNA2Graph automates the identification of non-linear DNA molecules in electron microscopy images, significantly reducing the need for manual review and improving structure detection.

This study investigates how telomeres impede replication by showing G-rich DNA and shelterin subunit POT1 block lagging strand replication, with POT1 causing Okazaki fragment skipping and large single-stranded gaps.

This study shows that RNase H1 reduces DNA damage and improves SMA-like symptoms in a Drosophila model by resolving RNA:DNA hybrids caused by SMN deficiency.

The paper develops a method to enrich and purify centromeric DNA from human cells, achieving 25-fold enrichment and up to 60% centromeric content in sequenced fractions.

The paper shows that telomere damage leads to internal loops (i-loops) that can form extrachromosomal telomeric circles, contributing to telomere erosion.