Adaptive selection of p53 mutation metaplastic phenotypes in estrogen-independent progression of ER+ tumors: A mechanism for acquired resistance to hormonal therapy.
Hyeongsun Moon, Hidetoshi Mori, Jane Chen, Alejandra V. Patino, Zsófia Pénzváltó, Kavya Ramamurthy, Jaeyong Choi, John D. McPherson, Joshua C. Snyder, Robert D. Cardiff, Alexander D. Borowsky
This study shows that ER+ breast cancers can develop resistance to hormonal therapy through clonal selection of metaplastic p53-mutated basal cells in Stat1-/- mice.
bioRxiv · Feb 2, 2025 · PreprintCancer Biology