PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins
Yongjia Duan, Aiying Du, Jinge Gu, Gang Duan, Chen Wang, Xinrui Gui, Zhiwei Ma, Beituo Qian, Xue Deng, Kai Zhang, Le Sun, Kuili Tian, Yaoyang Zhang, Hong Jiang, Cong Liu, Yanshan Fang
This study shows PARylation regulates RNP granule dynamics and neurotoxicity of disease-related RNA-binding proteins, with PARP inhibition reducing neurotoxicity in ALS models.
Cell Research · Feb 6, 2019Peer-reviewedNeuroscience