Author
The University of Texas Southwestern Medical Center
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Ashlesha Gogate, Wei-Chen Chen, Mpathi Nzima…·Maria H. Chahrour
This study uses CRISPRi Perturb-seq to analyze 1,408 autism risk genes in human cortical neurons, identifying 215 genes that cause global transcriptomic dysregulation and uncovering shared transcriptional pathways.
Chikara Takeuchi, Sushama Sivakumar, Anjana Sundarrajan…·Gary C. Hon
The paper identifies dynamic regulatory network hubs in human lineage specification using Perturb-Seq and constructs a deep learning model to predict perturbed TFs in patient transcriptomes.
Jialei Duan, B Li, Kartik Kulkarni…·Gary C. Hon
The paper uses single-cell overexpression screens to study how combinations of transcription factors drive gene regulatory networks and cell-type specific gene expression programs.
Zachary Markham, Boxun Li, Landon Vu Nguyen…·Gary C. Hon
The paper introduces PEPR-GNN, a graph neural network framework to model regulome responses during genetic perturbations using Multiome Perturb-Seq data.
Gabriella M. Quinn, Daniel C. Propheter, Kartik Kulkarni…·Lora V. Hooper
This study shows dietary vitamin A enhances intestinal antimicrobial defenses by promoting REG3 lectin and defensin expression through retinoic acid receptor signaling.