J. Roelands

Revisiting colorectal cancer tumorigenesis with spatially-resolved gene expression profiling

This study uses spatially-resolved gene expression profiling to analyze molecular changes in colorectal cancer from healthy tissue to cancer, identifying potential biomarkers and highlighting the role of the innate immune system.

The Immune landscape of solid pediatric tumors.

This study characterizes immune subtypes in solid pediatric tumors using gene expression data, finding distinct immune signatures and survival associations.

Pazopanib induces dramatic but transient contraction of myeloid suppression compartment in favor of adaptive immunity

This study shows pazopanib reduces myeloid suppression and boosts adaptive immunity in mRCC patients, with effects peaking at 3 months.

Germline genetic contribution to the immune landscape of cancer

This study identifies germline genetic variants associated with immune traits in cancer, revealing their impact on the tumor immune microenvironment.

Genomic landscape of tumor-host interactions with differential prognostic and predictive connotations

The paper analyzes tumor-host interactions across 31 cancer types using the ICR signature to identify prognostic and predictive implications of immune phenotypes.

Elevation of FAM129A in neutrophils exposed to serum of patients with severe sepsis: in silico investigations during a hands on training workshop and follow on validation of protein expression in neutrophils

The paper investigates FAM129A expression in neutrophils exposed to sepsis serum using transcriptome data and confirms surface expression through bench validation.

The abundance of Nudix hydrolase 16 transcripts is elevated in human sepsis: perspectives gained during a hands-on reductionist investigation workshop.

The paper investigates NUDT16 transcript abundance in sepsis using omics data and public datasets, finding elevated levels in septic patients compared to controls.