L. Crozier

Oncogenic signals prime cancer cells for toxic cell growth during a G1 cell cycle arrest

This paper shows CDK4/6 inhibitors cause toxic cell growth in cancer cells during G1 arrest due to oncogenic signals, which can be reversed by targeting mTOR.

Cell overgrowth during G1 arrest triggers an osmotic stress response and chronic p38 activation to promote cell cycle exit

The paper shows that CDK4/6 inhibitor-induced G1 arrest causes cell overgrowth, triggering osmotic stress and p38-p53-p21 signaling to promote cell cycle exit.

CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal

This study shows CDK4/6 inhibitors cause long-term cell cycle withdrawal by inducing replication stress and p53-dependent effects, linking them to genotoxic stress and potential combination therapies.

Division of labour between different PP2A-B56 complexes during mitosis

This study identifies how different PP2A-B56 isoforms localise to distinct mitotic structures through specific protein interactions, controlling key mitotic processes.