R. Foy

Oncogenic signals prime cancer cells for toxic cell growth during a G1 cell cycle arrest

This paper shows CDK4/6 inhibitors cause toxic cell growth in cancer cells during G1 arrest due to oncogenic signals, which can be reversed by targeting mTOR.

Effects of ocean acidification on red king crab larval survival and development

This study examines the effects of ocean acidification on red king crab larvae, finding no significant differences in survival or development across pH treatments.

The search for CDK4/6 inhibitor biomarkers has been hampered by inappropriate proliferation assays

This paper shows that ATP-based proliferation assays overestimate CDK4/6 inhibitor response due to G1 cell overgrowth, and identifies Cyclin D1 and RB1 as potential biomarkers using DNA-based assays.

Effects of high pCO2 on snow crab embryos: Ocean acidification does not affect embryo development or larval hatching

This study examines the effects of ocean acidification on snow crab embryos over two years, finding no significant impact on development, hatching success, or adult calcification.

Effects of high pCO2 on snow crab larvae: Carryover effects from embryogenesis and oogenesis reduce direct effects on larval survival

This study examines the effects of ocean acidification on snow crab larvae, finding that carryover effects from embryogenesis and oogenesis reduce direct negative impacts on larval survival.

Cell overgrowth during G1 arrest triggers an osmotic stress response and chronic p38 activation to promote cell cycle exit

The paper shows that CDK4/6 inhibitor-induced G1 arrest causes cell overgrowth, triggering osmotic stress and p38-p53-p21 signaling to promote cell cycle exit.

CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal

This study shows CDK4/6 inhibitors cause long-term cell cycle withdrawal by inducing replication stress and p53-dependent effects, linking them to genotoxic stress and potential combination therapies.