R. H. Whitaker

CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal

This study shows CDK4/6 inhibitors cause long-term cell cycle withdrawal by inducing replication stress and p53-dependent effects, linking them to genotoxic stress and potential combination therapies.

Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth

The paper develops DPY30-targeting peptides that inhibit blood cancer cell growth by disrupting ASH2L binding and H3K4 methylation.