B. H. Park

Oncogenic signals prime cancer cells for toxic cell growth during a G1 cell cycle arrest

This paper shows CDK4/6 inhibitors cause toxic cell growth in cancer cells during G1 arrest due to oncogenic signals, which can be reversed by targeting mTOR.

In vitro formation and extended culture of highly metabolically active and contractile tissues

This study develops porous PDMS molding techniques to improve extended culture of contractile and metabolically active 3D cell cultures, showing increased cell density and maturation with optimized surface treatments and feeding schedules.

Enhanced Peripheral Nerve Regeneration by Mechano-electrical Stimulation

This study uses piezoelectric nerve conduits and mechano-electrical stimulation to enhance peripheral nerve regeneration in a rat model, achieving full axon reconnection and functional recovery.

Targeting metabolic adaptations in the breast cancer liver metastatic niche using dietary approaches to improve endocrine therapy efficacy

This study identifies a mechanism of endocrine resistance in liver metastases of ER+ breast cancer and shows that a fasting-mimicking diet enhances the efficacy of fulvestrant treatment.

Hotspot ESR1 mutations are multimodal and contextual drivers of breast cancer metastasis

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.